Se-containing spirulina phycocyanin attenuated liver injury induced by carbon tetrachloride in mice
- VernacularTitle:含硒藻蓝蛋白抗小鼠实验性肝损伤的作用
- Author:
Zhi HUANG
;
Wenjie ZHENG
;
Junjian XIANG
;
Fang YANG
;
Baojian GUO
- Publication Type:Journal Article
- Keywords:
Phycocyanin;
Selenium;
Liver;
Glutathione peroxidase
- From:
Chinese Journal of Pathophysiology
2000;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of Se-containing spirulina phycocyanin (Se-SPC) on liver injury of mice induced by carbon tetrachloride (CCl 4). METHODS: The mouse model was conducted by intragastric feeding with 2% CCl 4 oil for three times, meanwhile Se-SPC, spirulina phycocyanin (SPC) and Na 2SeO 3 were injected (ip) to various groups for 7 days. Then selenium (Se), glutathione peroxidase (GPx), superoxide dismutase (SOD), alanine aminotransferase (ALT), malondiaoldehyde (MDA) and nitric oxide (NO) levels in blood and liver were measured. RESULTS: The level of Se, GPx and SOD activities were obviously higher ( P
