Protective Effect of Ligustrazin on the Mitochondrial Damage of Myocardium in Ischemiareperfusion Rats
- VernacularTitle:川芎嗪对大鼠心肌线粒体损伤的保护作用
- Author:
Lamei XIA
- Publication Type:Journal Article
- Keywords:
ligustrazin;
ischemia-reperfusion damage of myocardium;
mitochondrion;
adenosine triphosphatase;
respiratory enzymes
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of ligustrazin on the mitochondrial damage of myocardium in ischemia-reperfusion rats and the mechanism involved METHODS:Rat model of myocardial ischemia-reperfusion injury was established by coronary artery ligation and the activities of Ca2+-ATPase,Ca2+?Mg2+-ATPase,succinic dehydrogenase(SDH),cytochrome oxidase(CCO),SOD,GSH-PX and contents of phospholipid(PL),MDA,Cyt aa3 and Cyt C in the myocardial mitochondria were observed RESULTS:As compared with ischemia-reperfusion group(IR),IR+L(ligustrazin)group showed significant increase in the activities of Ca2+-ATPase,Ca2+?Mg2+-ATPase,SDH,CCO,SOD and GSH-PX(P
