Renoprotective Effects of Benazepril on Rats Kidney After Unilateral Ureteral Obstruction
- VernacularTitle:苯那普利对单侧输尿管梗阻大鼠肾脏的保护作用
- Author:
Hua SHUI
;
Lianfang XU
;
Deji CHEN
- Publication Type:Journal Article
- Keywords:
Ureter,obstruction;
Benazepril;
Animal model,rat
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of renal interstitial fibrosis after unilateral ureteral obstruction and renal protctive effect of angiotensin coverting enzyme inhibitor (ACEI),benazepril on rat kidney.Methods Twenty-four rats were randomly assigned to shame operation group (normal group),operation group, benazepril(10mg?kg -1 ?d -1 ) treatment group after unilateral ureteral obstruction. Renal tissues were examined by light and electronmicroscopy at the 2nd week after operation. Immunohistochemistry was applied to measure the expression of collagen Ⅲ,transforming growth factor ? 1 (TGF-? 1 ) and nuclear factor-kB(NF-kB) in the renal interstitium.Results In comparison with shame operation group, the expression of collagen Ⅲ , TGF-? 1 and NF-kB in the interstitium of operation group markedly increased (P
