Research on the Anti-Calcification Feature of Polydiol Post-Treatment of Glutaraldehyde Tanned Bovine Pericardium
- VernacularTitle:混合醇对戊二醛鞣制的牛心包防钙化改性的实验研究
- Author:
Wei ZHANG
;
Guangfu GONG
;
Jianguo HU
- Publication Type:Journal Article
- Keywords:
Bovine pericardium;
Anticalcification;
Mixed alchol;
Polydiol, Glutaraldehyde;
Aminal model,rat
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The polydiol, such as 1,2-propanediol, 1,3-propanediol,2,3-butanediol, was first used for the post-treatment of G-tBP,in order to find new fixative, for anticalcification, improving durability and clinical use. Method G-tBP with the polydiol post-treated were implanted sabcutaneously in back of weanling SD rats.60 days after the treatment,calcium concentration analysis,histologic examination,electron microscopy,heat shrink temperature and tissue humidity were tested.Results The polydiol-post treated bovine pericardium showed less calcification significantly as compared with the G-tBP after 60 days implantation(mean tissue clacium content(1 817?3 091) versus (176 32?43 27)?g/mg dry weight, P0 05). Conclusions ⑴G-tBP with the polydiol post-treated appears less calcification. ⑵The effect of polydiol post-treatment on anticalcification is correlated to the tanned temperature, at 25℃ is more effective than at 4℃.
