Observation on the Ratio of Apoptosis and Proliferating Cell Nuclear Antigen in Gastric Carcinoma
- VernacularTitle:胃癌组织中细胞凋亡与增殖细胞核抗原比值关系的研究
- Author:
Shanling GAO
;
Bingbing SHEN
;
Hui XING
- Publication Type:Journal Article
- Keywords:
Gastric carcinoma;
Apoptosis,cell;
Proliferation Cell Nuclear Antigen;
Ratio;
Prognosis
- From:
Journal of Chinese Physician
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the ratio of apoptosis to proliferating cell nuclear antigen(PCNA) in gastric carcinoma(GC) and elucidate the possible role of apoptosis and proliferation in the development of GC.Methods Apoptosis and PCNA were examined in 24 cases with gastric carcinoma and in 24 cases of the surrounding non-cancerous tissue embedded in paraffin by TUNEL and immunohistochemical staining technique respectively.Results The study indicated that the proliferation labeling indices(PIs) in GC(51 2) was significantly higher than that in the surrounding non-cancerous tissue(27 4),and the apoptotic indices(AIs) in GC(3 1) was significantly lower than that in the surrounding non-cancerous tissue(5 4)(P
