Significance in expression of GST-Pi,ToPoII and PgP resistance drug gene in breast carcinoma
- VernacularTitle:乳癌组织中GST-Pi,ToPoII和PgP耐药基因的表达
- Author:
Longzhen YE
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/genet;
GENE EXPRESSION;
RESISTANCE DRUG GENE;
DRUG TOLERATION
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and biological significance of resistance gene of GST Pi,ToPoII and PgP in breast carcinoma. Method To test and analyse the resistance gene for GST Pi,ToPoII and PgP of 52 cases of breast carcinoma was made by using instant microwave heating immunohistochemistry.Results (1) Positive expression rates of GST Pi,ToPoII and PgP in 52 cases of breast carcinoma were 50.0% (26/52), 17.3% (9/52) and 11.5%(6/52),respectively. (2) Invasive ductal carcinoma had positive expression of three resistance genes at different levels,and the resistance genes in invasive ductal carcinoma were more widely than those in other types breast cancer. (3) There was no obvious relationship between positive expression of GST Pi,ToPoII and PgP in breast carcinoma with patients' age. However,the positive expression of three resistance genes in patients aged 40 to 49 and aged 60 to 69 were higher than other ages.Conclusions (1) The multidrug resistance genes existing in some patients of breast carcinoma or the primary cancer cell has resistance to GST Pi,ToPoII and PgP antineoplastics. (2) Before chemotherapy to patients with breast carcinoma, the test of resistance gene should be done, which will help doctors select a resonable method of combination of drugs so as to improve curative effect and to prolong patients' life.
