Inhibitory effects of dexamethasone on the expression of integrin CD18 induced by PMA
- VernacularTitle:地塞米松对PMA诱导CD18表达的抑制作用
- Author:
Xiaowen HE
;
Yujian LIU
;
Jun LI
;
Zhen PAN
;
Jigen ZHONG
;
Jia LU
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Phorbol esters;
NF-kappa ?;
RNA,messenger
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of dexamethasone(Dex) on the expression of CD18. METHODS: Quantitative RT-PCR analysis, Northern blotting technique were used to measure the expression of CD18 in U937 cells treated by PMA. RESULTS : Dex could significantly attenuated the effects of PMA in a dose-dependent manner (10 -6 mol/L-10 -10 mol/L). These effects of Dex (10 -7 mol/L) were completely aborted by RU-486 (10 -6 mol/L).CONCLUSION: Dex, via GR, could inhibit CD18 mRNA expression in U937 cells treated by PMA. The effects of Dex might be possibly depended on the counteracting action on the NF-?B.
