Alteration of local renin-angiotensin system of dogs with myocardial ischemia and external counterpulsation treatment
- VernacularTitle:局部肾素-血管紧张素系统在反搏治疗心肌缺血时的改变及其机制
- Author:
Li LU
;
Weikang WU
;
Zhensheng ZHENG
;
Xiaoxia QIAN
- Publication Type:Journal Article
- Keywords:
Myocardial ischemia;
Renin-angiotensin system;
Counterpulsation
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To examine the alteration of local renin-angiotensin system of dogs with myocardial ischemia and external counterpulsation treatment and its mechanism. METHODS: Acute myocardial ischemia was induced by occluding the LAD of ischemic and ECP groups. The tissue renin activity and angiotensin(AngⅡ) level in ischemic myocardium and aorta were measured. The expression of angiotensinogen and renin mRNA were detected by RT-PCR. RESULTS: Renin activity, AngⅡ level in ischemic myocardium and AngⅡ level in aorta of ECP group were lower than those of MI group. Except for renin in ischemic myocardium, angiotensinogen mRNA and renin in ischemic myocardium and angiotensinogen mRNA in aorta of ECP group were reduced to normal level. CONCLUSION: The inhibitory effect of ECP on cardiovascular renin activity and angiotensinogen gene expression could be one of the mechanisms by which ECP protects ischemic myocardium.
