Effect of L-arginine on nitric oxide and brain edema after subarachnoid hemorrhage in rats
- VernacularTitle:L-精氨酸对大鼠蛛网膜下腔出血后一氧化氮含量及脑水肿的影响
- Author:
Baoliang SUN
;
Zuoli XIA
;
Mingfeng YANG
;
Baolin GE
;
Pingming QIU
;
Sumin ZHANG
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Brain edema;
Nitric oxide;
Arginine;
Rats
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of nitric oxide in the development of brain edema after subarachnoid hemorrhage(SAH), and the influence of L-arginine on them. METHODS: Noncraniotomy models of SAH in Wistar rats were used and animals were divided into sham-operated group, SAH group and SAH plus L-arginine group. Dynamic changes of regional cerebral blood flow within 24 hours were measured. Serum nitric oxide level, brain water and sodium content at different time points within 24 hours were also detected. RESULTS: Regional cerebral blood flow and serum nitric oxide level at every time point after operation in SAH group were lower than those in sham-operated group, while brain water content and sodium content in the former group were higher than those in the latter group. Above pathological alterations in SAH plus L-arginine group were not so obvious as in SAH group. CONCLUSION: Decrease in serum nitric oxide plays a role in the development of brain edema after SAH, which may be partly reversed by administration of L-arginine.
