Relationship between helper Tlymphocytes immune deviation and classⅡMHC antigen expression in acute rejection of transplanted heart
- VernacularTitle:移植心Th细胞免疫偏离与MHCⅡ类抗原表达的关系
- Author:
Zhenguang CHEN
;
Peiwu SUN
;
Peng XIANG
;
Xiuming ZHANG
;
Yan LI
;
Xi ZHANG
;
Shunon LI
- Publication Type:Journal Article
- Keywords:
Heart transplantation;
T-lymphocytes;
Acute immune rejection
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the relationship between the immune deviation of Th1 and Th2 cell clones and class Ⅱ major histocompatibility complex (MHC) antigen expression in different stages of acute rejection in transplanted hearts. METHODS: Heart transplantation were performed in rats.Isografts and non-transplanted animals were used as control group. Donor class II MHC antigen expression were detected with monoclonal antibodies and immunostaining technique and the amount of type Ⅰ and Ⅱ cytokines mRNA expression were detected by semiquantitative RT-PCR in cardiac allografts. RESULTS: Myocardial IL-2 mRNA and donor class Ⅱ MHC antigen expression were significantly in creased, accompanied with development of acute rejection( P
