Pathogenesis of early cardiac myocyte damage after severe crush injury
- VernacularTitle:严重挤压伤大鼠早期心脏损伤的某些发病机制的探讨
- Author:
Shuiping LIU
;
Yuchuan CHEN
;
Xiuqin LIU
;
Wei GUO
;
Jiandin CHENG
- Publication Type:Journal Article
- Keywords:
Crush syndrome;
Endothelin-1;
Atrial natriuretic factor;
Troponin
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the changes of plasma atrial natriuretic peptide(ANP), endothelin-1 (ET-1) and serum cardiac troponin I(cTnI) levels and the effects of ANP and ET-1 on myocardium in crush injury rats. METHODS: Crush injury was produced in SD rats,the serum levels of cardiac enzyme and cardiac troponin I,plasma levels of ANP and ET-1 were studied by automated biochemical analyzer,automated chemiluminescence assay and radioimmunoassay. RESULTS: The plasma ET-1 level was much lower ,the levels of plasma ANP and serum cardiac enzyme and cTnI were much higher after crush injury than those of the control group( P
