Effects of liver regeneration on the proliferation of rat fetal hepatocytes after intrasplenical transplantation
- VernacularTitle:肝再生对大鼠胎肝细胞脾内移植后增殖的影响
- Author:
Mingzhi YANG
;
Jun MIN
;
Jisheng CHEN
;
Xiaodong ZHOU
;
Jin WEI
- Publication Type:Journal Article
- Keywords:
Liver regeneration;
Fetal hepatocyte;
Transplantation;
Spleen;
Proliferation
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of environment of liver regeneration on the proliferation of rat fetal hepatocytes after intrasplenical transplantation. METHODS: Fetal hepatocytes isolated from 3-week SD rat fetuses bred were transplanted into the spleens of liver regeneration model rats with 70% partial hepatectomy. The cell cycle of the hepatocytes in the remnants liver was analyzed by flow cytometer and the density dimensions of the donor fetal hepatocytes in spleen were measured by image analysis system 7 and 30 days post-transplantation, respectively. RESULTS: Compared with the control group, the proportions of S and G 2/M cells in the remnants liver were obviously decreased ( P
