Effect of lansoprazole on gastric ulceration in rats
- VernacularTitle:兰索拉唑抗实验性胃溃疡作用的研究
- Author:
Hua XU
;
Liping YU
;
Jie WEN
;
Wen ZHAO
;
Yadong HUANG
;
Xiaoku LI
- Publication Type:Journal Article
- Keywords:
Lansoprazole;
Shock, hemorrhagic;
Stomach ulcer;
Stress;
Rats
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of lansoprazole on gastric ulceration in rats. METHODS:Using the gastric ulcer model induced by hemorrhagic shock, restraint water-immersion stress and pylorus-ligature, the protective effect of lansoprazole (iv) on gastric ulceration was observed. RESULTS: Pretreatment with lansoprazole (7.5-60 mg/kg) significantly inhibited the formation of gastric ulcer in the three models in a dose-dependent manner. The autiulcer efficacy of lansoprazole was similar to that of omeprazole in the equal dose, but stronger than that of omeprazole for ulcer induced by water-immersion stress. CONCLUSION: The intravenously administered lansoprazole inhibited formation of experimental gastric ulcer in rats.
