Expression of TIMP-1 in human breast cancer and its implication
- VernacularTitle:乳腺癌组织中组织金属蛋白酶抑制剂-1的表达及其意义
- Author:
Zhixin YAN
;
Shilin ZOU
;
Xiudi XIAO
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Tissue inhibitor of metalloproteinases;
Neoplasm metastasis;
Prognosis
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical singnificance of metalloproteinase(TIMP) 1 expression in human breast cancer.Methods The expression of TIMP 1 in paraffin embedded breast carcinoma specimens from 48 patients with primary invasive breast cancer who had undergone radical mastectomy or modified radical mastectomy from January of 1990 to Dcecember of 1996 were detected by the standard streptavidin biotin peroxides method,and its correlation to clinicopathologic featurea was analyzed. Ruslts Among 48 cases,the positive expression rate of TIMP 1 was 29%, TIMP 1 expression were higher in patients with higher histological grades than in those with lower ( P
