Overexpression of p38 MAPK protein in breast cancer and the regulation of preoperative chemotherapy
- VernacularTitle:p38在乳腺肿瘤中的表达及术前化疗对其的影响
- Author:
Feifei YAN
;
Shan WANG
;
Xueguang ZHU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Protein kinases;
Blotting, western;
Immunohistochemistry
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate p38 MAPK protein expression in human breast tumors and the regulation of preoperative chemotherapy. MethodsWe assessed p38 MAPK protein in 50 cases of breast cancer and adjacent normal tissue and that of breast benign tumors in 14 cases by Western blot. 15 cancer patients received preoperative CAF or TA protocol. Results The p38 protein level in tumors was significantly greater than that in the normal tissues, while there was not significant difference between benign tumors and corresponding normal tissue. p38 protein T/N ratio was higher in patients with lymph node metastasis than patients without( P
