Study on the Release Rate and Bioavailability of Aspirin Sustained Release Capsules
- VernacularTitle:阿司匹林缓释胶囊的释放度与生物利用度研究
- Author:
Ning LIN
;
Xuecheng XIAO
;
Zeping RAO
;
Yuanhong LI
;
Guanglin DING
- Publication Type:Journal Article
- Keywords:
aspirin;
sustained release capsule;
release rate;
bioavailability
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Aspirin sustained release capsules(A-SRC) were prepared The release rate and bioavailability of A-SRC were studies METHODS:To study release mechanism by determining dissolution rate and to study relative bioavailability of A-SRC by determining serum concentrations in rabbits RESULTS:The release profile of A-SRC fitted zero-order kinetics This sustained release preparation had good release stability and high bioavailability in comparison with commonly-used aspirin sustained release capsules CONCLUSION:A-SRC showed obviously sustained release effect The drug concentration in blood kept steady and lasted long after oral administration,therefore the times of administration could be decreased Because the light-excipients were used in A-SRC,which had floating properties and could make drug release slowly A-SRC could decrease the irritations to gastrointestinal tract and other side effects
