The Change of Endothelin-1 and Calcitonin Gene-related Peptide in Neonatal Hypoxic-ischemic Encephalopathy and Its Influence on Cerebral Hemodynamics
- VernacularTitle:缺氧缺血性脑病患儿血浆内皮素1与降钙素基因相关肽变化及其对脑血流动力学的影响
- Author:
Xiuxia GUO
;
Haiying CAO
;
Yingfen DI
- Publication Type:Journal Article
- Keywords:
Infant, newborn;
Cerebral ischemid;
Cerebral anoxia;
Endothelin 1;
Calcitonin gene related peptide;
Hemodynamics
- From:
Chinese Journal of Perinatal Medicine
1998;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the variation of endothelin 1(ET 1) and calcitonin generelated peptide(cGRP) and its clinical implication, and to analyze the influence of ET 1 and cGRP on cerebral arteries hemodynamics in neonates with hypoxic ischemic encephalopathy(HIE). Methods The variation of ET 1,cGRP in cord blood and peripheral blood were prospectively observed at the time of 1 day,3 days and 7 days after birth in HIE and healthy control infants by radioimmuneassay. The cerebral arteries hemodynamics were determined immediately using color Doppler ultrasonography at 1 day after blood samples were obtained. Results (1) The following factors in cord blood and vein one day after birth in neonatal HIE and healthy controls was: ET 1(70?25)ng/L vs (38?19) ng/L ( P
