Modification of enzymatic antioxidants in bovine retinal capillary pericytes by advanced glycation end products
- VernacularTitle:糖基化终产物对牛视网膜毛细血管周细胞内抗氧化能力的影响
- Author:
Baihua CHEN
;
Deyong JIANG
;
Luosheng TANG
- Publication Type:Journal Article
- Keywords:
Pericytes/metabolism;
Glycosylation end products,advanced;
Catalase;
Malondialdehyde;
Diabetic retinopathy/metabolism
- From:
Chinese Journal of Ocular Fundus Diseases
1999;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of advanced glycation end products (AGEs) on the catalase activity and the levels of malondialdehyde in cultured bovine retinal capillary pericytes (BRPs), and to investigate the relationship between oxidative stress and diabetic retinopathy. Methods Cultured BRPs were exposed to AGEs (0, 8, 32, 125, 500, 2 000 ?g/ml) for four days. Activity and the levels of catalase and malondialdehyde in cultured BRPs were examined by spectrophotometry. Results AGEs decreased the catalase activity, whereas increased the levels of malondialdehyde of cultured BRPs in a dose dependent manner ( r=-0.714, r=0.748, P
