Effects of L-arginine on the production of extracellular matrix of human mesangial cells
- VernacularTitle:L-精氨酸对人肾系膜细胞胞外基质产生的影响
- Author:
Kunling MA
;
Bicheng LIU
;
Yinying YE
;
Naifeng LIU
;
Xiongzhon RUAN
- Publication Type:Journal Article
- Keywords:
Arginine;
Glomerular mesangium;
Collagen
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of L-arginine(L-arg) on the production of collagens of human mesangial cells. METHODS: Radioimmunoassay, hydroxyproline colorimetric assay and reverse transcription polymerase chain reaction (RT-PCR) were used to determine procollagen Ⅲ, total collagen level in the supernatant and expression of collagen Ⅳ mRNA in human mesangial cells. RESULTS: L-arg significantly inhibited the production of procollagenⅢ, total collagen in the supernatants ( P
