Effects of carbon monoxide on hypoxia inducible factor-1expression in hypoxia preconditioned mice
- VernacularTitle:一氧化碳对缺氧预适应小鼠缺氧诱导因子-1表达的影响
- Author:
Yuanjing LIANG
;
Guowe LU
- Publication Type:Journal Article
- Keywords:
Anoxia;
Preconditioning;
Carbon monoxide;
Blotting, Western;
Mice
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of carbon monoxide (CO) on hypoxia inducible factor-1? (HIF-1?) expression and on hypoxic tolerance duration in hypoxia preconditioned mice. METHODS: Mice were injected with normal saline (NS) or hemin intraperitoneally. Western blot was used to detect HIF-1? in hippocampus. The tolerant duration of each hypoxic run was recorded. RESULTS: After 1 and 2 runs of hypoxia exposure, there were no significant differences in HIF-1? expression and hypoxic tolerance duration between N and hemin injection groups. After 3 and 4 runs of hypoxia exposure, the content of HIF-1? was lower and hypoxic tolerance duration was shorter ( P
