Effects of cimetidine on platelet function and thrombosis
- VernacularTitle:西咪替丁对血小板功能及血栓形成的影响
- Author:
Changlong LIAO
;
Qiyun LI
;
Guang XU
;
Xionggen LI
;
Xinzhou ZHANG
;
Wangfan ZHANG
- Publication Type:Journal Article
- Keywords:
Cimetidine;
Platelet aggregation;
Thrombosis;
Calcium
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of cimetidine(Cim) on platelet function and thrombosis. METHODS: After incubated with Cim in vitro , rat platelets were activated with ADP or thrombin. The platelet aggregation, platelet malondialdehyde(MDA) formation, platelet intracellular free calcium([Ca 2+ ] i), and thromboxane B 2 (TXB 2) were measured. The effects of Cim on electric-induced thrombosis in rat carotid artery were examined. RESULTS: Cim potentiated ADP induced platelet aggregation , increased the thrombin induced [Ca 2+ ] i and MDA formation, decreased TXB 2. Also, Cim shortened the duration of electric-stimulated occlution time in rat carotid artery. CONCLUSION: Cim increased platelet function and accelerated thrombosis.
