Stress induced expression of the angiotensinogen gene in rat anterior pituitary
- VernacularTitle:应激时大鼠垂体前叶血管紧张素原基因表达增强
- Author:
Yong XU
;
Suzhen ZHANG
;
Yu WAN
;
Gang YANG
;
Zhijiao TANG
;
Jianmi HU
- Publication Type:Journal Article
- Keywords:
Stress;
Pituitary gland, anterior;
Angiotensinogen;
Hybridization
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of angiotensinogen (ANG)mRNA and the changes of AngⅡ content in rat anterior pituitary during acute stress.METHODS: The expression of ANG mRNA was determined using in situ hybridization technique, and the AngⅡ content were determined by RIA.RESULTS: The ANG mRNA expression and AngⅡ content were significantly increased, and ANG mRNA was increased more significantly than AngⅡ content. CONCLUSION: The local renin-angiotensin system (RAS) in anterior pituitary is obviously activated during stress, which strongly supports the view that local RAS contributes to stress reaction.
