Analysis of p16 gene deletion and mutation in gastric carcinoma
- VernacularTitle:胃癌中p16基因缺失与突变的研究
- Author:
Guohai ZHAO
;
Tiechen LI
;
Lianghui SHI
;
Yabin XIA
;
Huilan SUN
;
Dunf PENG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Genes, p16;
Homozygous deletion;
Gene mutation
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate p16 gene alterations in gastric carcinoma. METHODS: 36 fresh tumor specimens taken from gastric cancer patients were analyzed for p16 gene deletion and mutation by polymerase chain reaction (PCR) and DNA sequencing. RESULTS: Homozygous deletion of exon 1 and exon 3 was observed in 2 cases and 3 cases of diffuse carcinoma, respectively. The frequency of homozygous deletion was 13.89%. No p16 gene point mutation was detected. CONCLUSION: The deletion of p16 genes may be related to gastric carcinogenesis.
