Basic fibroblast growth factor and Alzheimer's disease
- VernacularTitle:碱性成纤维细胞生长因子与阿尔茨海默病
- Author:
Daming ZHU
;
An HONG
;
Jian LIN
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Fibroblast growth factor;
basic;
Cells;
Apoptosis;
Proteins
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD),which is one type of senile deimentia, has three remarkable pathologic characteristics-senile plaque,neurofibrillar tangles and neuronal death. As a neurotrophic factor, basic fibroblast growth factor(bFGF)is closely related to AD. This article reviewed the interaction between bFGF and AD-associated gene products(such as amyliod ? protein,presenilin, apoloprotein E and microtubulin associated protein tau)and neuronal apoptosis. Some researchers suggested that bFGF may be put forward as potential therapeutic agent in AD and play a role in preventing or retarding the pathological process of this disease, alleviating or even eradicating the pathological insults of this disease.
