A study of photodynamic therapy on experimental pancreatic cancer in a nude mouse model
- VernacularTitle:光动力疗法对裸鼠实验性胰腺癌治疗机制的研究
- Author:
Bo ZHANG
;
Yupei ZHAO
;
Taiping ZHANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Photochemotherapy;
Vascular injury
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the therapeutic effect and the mechanism of photodynamic therapy (PDT) on human pancreatic cancer xenograft in nude mice.MethodsThe animal model of human pancreatic cancer was produced by injecting human pancreatic cancer cells SW1990 into the dorsum of nude mice. After photosensitizer hematoporphyrin derivatives(HpD) was injected, the 632.8?nm He Ne laser was used to irradiate the tumor. The tumor′s volume was measured and factor Ⅷ was used for the immunohistochemical staining of the vessel change.ResultsThe tumor growth rate significantly decreased after PDT. Immunohistochemical staining showed significant vessel endothelial cell injury by PDT.ConclusionsPDT has a therapeutic effect on grafted pancreatic cancer possibly by incurring vascular injury.
