Expression of RANKL in gastric carcinoma and its relationship to pathological parameters
- VernacularTitle:RANKL基因在胃癌中的表达及与病理因素的关系
- Author:
Huanxing YANG
;
Heguang HUANG
;
Faduan YANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Pathology, clinical;
Prognosis;
Genes
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the expression of RANKL′s protein for the diagnosis and assessment of tumor metastatic potential and prognosis in patients with gastric carcinoma.MethodsThe expression of RANKL was detected in 45 cases of gastric carcinoma, 26 cases of paracancerous mucosa and 10 cases of healthy control by using ABC immunohistochemical method. Data were tested by ? 2 test for statistical significance.ResultsPositive expression of RANKL protein was detected in 21 out of 45(46 7%) cases. The expression of RANKL significantly increased in tumors ≥5?cm in diameter, with serosa infiltrated, positive lymph node, and in tumors of stage Ⅱ,Ⅲ,Ⅳ( P
