The Effects of Diltiazem on the Blood Concentration and Renal Toxicity of CsA
- VernacularTitle:地尔硫对环孢素A肾毒性的防护及血药浓度的影响
- Author:
Xilan TANG
;
Xiangzhi SONG
;
Liangqing HONG
- Publication Type:Journal Article
- Keywords:
cyclosporin A;
diltiazem;
renal transplantation;
serum concentration of drug
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of diltiazem on the blood concentration and the renal toxicity of cyclosporin A(CsA) in patients with renal transplantation.METHODS: 25 patients with renal transplantation were divided into two groups,the therapeutic group were treated with diltiazem plus CsA and control group CsA alone and the valley blood concentration of CsA was detected by FPIA assay.RESULTS:The dosage of CsA in therapeutic group was less than that in control group significantly,the levels of UA,Scr and BUN in patients were decreased by diltiazem.CONCLUSION:The diltiazem therapy can decrease the dosage and toxic effect of CsA,then save the patient's medical costs.
