The Inhibition of Losartan to Glomerulosclerosis in SHR
- VernacularTitle:洛沙坦对高血压鼠肾小球硬化延缓作用的研究
- Author:
Jun WU
;
Ming SUN
;
Hongyan ZHOU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Glomerulosclerosis;
AngiotensinⅡ;
AngiotensinⅡ receptor antagonist
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanisms of angiotensinⅡ receptor blockade in protection against kidney lesion in hypertensive rats.Methods The investigation was comprised with normotensive control (WKY) and hypertensive group (SHR) which included treated and untreated group. Relevant index such as blood pressure and ultrastructural changes in glomerulus with transmission electronic microscope were acquired in three-month old and eight-month old. Losartan was administrated with 20mg?Kg -1 ?d -1 in treated group.Results The volume density of vessel endothelium, mesangial cells and mesangial area of SHR was significantly larger than that of WKY(P
