The potential role of staphylococcal enterotoxin B in the early intestinal injury in postburn Staphylococcus aureus sepsis
- VernacularTitle:金葡菌肠毒素B在烫伤脓毒症大鼠早期肠损害中的作用及意义
- Author:
Hongyun LI
;
Yongming YAO
;
Zhiguo SHI
;
Ning DONG
;
Yan YU
;
Lianrong LU
;
Zhiyong SHENG
- Publication Type:Journal Article
- Keywords:
Burns;
Staphylococcus aureus;
Enterotoxins;
Endotoxins
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of staphylococcal enterotoxin B (SEB) in early intestinal injury in scald rats with Staphylococcus aureus sepsis. METHODS: 86 male Wistar rats were randomly divided into four groups as follows: normal controls ( n= 10), scald control group( n= 10), postburn sepsis group( n= 50) and SEB monoclonal antibody (MAb)treatment group ( n= 16). Plasma samples were collected to determine SEB, endotoxin, tumor necrosis factor-? (TNF-?) and interferon-? (IFN-?). RESULTS: After scald injury followed by Staphylococcus aureus challenge, the levels of SEB, TNF-? and IFN-? in plasma were significantly higher than those of normal controls, peaking at 2-6 h ( P
