Glycine protection against the myocardial ischemic injury in mice
- VernacularTitle:甘氨酸对小鼠心肌缺血性损伤的防治作用研究
- Author:
Qiong ZHOU
;
Daxiang LU
;
Yongmei FU
;
Huadong WANG
- Publication Type:Journal Article
- Keywords:
Myocardial ischemia;
Glycine;
Nitric-oxide synthase;
Superoxide dismutase;
Malondiadehyde
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of glycine on the myocardial ischemic injury in mice METHODS: Mice were supplied with 20% glycine twice daily (0 025 mL/g, ig), or 40% Injection salviae miltiorrhizae composita (ISMC, 0 025 mL/g, ig) One week later, 0 02 U/g pituitrin was injected intraperitoneally The electrocardiogram was recorded, and activities of nitric oxide synthase (NOS), superoxide dismutase (SOD) and the content of malondiadehyde (MDA) in the myocardium were examined RESULTS: Glycine reduced changes in J spot in electrocardiogram Both glycine and ISMC increased activities of SOD and NOS, inhibited increase in MDA content in the myocardium induced by pituitrin There was no difference in above parameters between glycine-treated and ISMC-treated mice. CONCLUSION: These results demonstrated that glycine can protect myocardium from ischemic injury, the mechanism may be related to increase in activities of NOS, SOD and supressing the lipid peroxidation.
