Apoptosis and expression of its regulating gene in gastric carcinoma and its precancerous lesions
- VernacularTitle:胃癌及其癌前病变中细胞凋亡及其调控基因的表达
- Author:
Shu SUN
;
Baiyan SUN
;
Huilan ZHI
;
Xiangfan XU
;
Dongzh SUN
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Apoptosis;
Protein p53;
Proto-oncogene proteins c-bcl-2;
Proto-oncogene proteins c-myc
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study apoptosis and the involved genes in malignant transformation of gastric carcinoma. METHODS: Apoptotic cell and apoptotic regulating gene p53,bcl-2,c-myc were detected in 46 cases with gastric carcinomas, 20 cases with precancerous lesions and 24 cases with normal mucosa in situ using TdT-mediated dUTP-biotin nick end labeling (TUNEL) technique and immunohistochemical stain. RESULTS: Apoptotic index in precancerous lesion(intestinal metaplasia and dysplasia) and gastric carcinoma were significantly higher than that in normal mucosa( P
