Changes of ultrastructure and level of nitric oxide in the myocardium of rats with experimental non-insulin-dependent diabetes mellitus
- VernacularTitle:一氧化氮在实验性NIDDM大鼠心肌病变中的变化
- Author:
Ming LEI
;
Xinqiu LIU
;
Fengyo XING
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, non-insulin-dependent;
Myocardial diseases;
Nitric oxide;
Nitric-oxide synthase
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:The ultrastructure,the levels of NO - 2/NO - 3 were investigated in the myocardium of rats with non-insulin dependent diabetes mellitus. METHODS: In order to establish a model of non-insulin dependent diabetes mellitus (NIDDM), we injected rats with small dose streptozocoi (iv). Two weeks after the injection, the rats developed impaired glucose tolerance. Then, they were fed with high energy diet for eight weeks to form NIDDM. RESULTS: (1) The ultrastructures of cardiac myocytes of NIDDM rats were changed evidently, with swelled mitochondrion and widened intercalated-disk gap; (2) The levels of NO - 2/NO - 3 in the heart tissue of NIDDM rats were significantly lower than those of normal rats( P
