Effect of Sini decoction on GST expression in the ischemic myocardium
- VernacularTitle:四逆汤对缺血心肌谷胱甘肽S转移酶基因表达的影响
- Author:
Hongmei TAN
;
Weikang WU
;
Hanchuan LUO
;
Mingqi ZHAO
;
Tianwen LIANG
- Publication Type:Journal Article
- Keywords:
Sini decoction;
Glutathione transferases;
Gene expression
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To detect the effect of Sini decoction on glutathione S-transferase (GST) mRNA expression in the ischemic myocardium. METHODS: Kunming mice were randomly divided into control group, ischemic group and Sini decoction group. Total RNA was extracted from the myocardium of mice in each group. The effect of Sini decoction on the expression of GST gene was detected by RT-PCR. RESULTS: The expression of GST mRNA in Sini decoction group was significantly up-regulated compared with the ischemic group and control group. CONCLUSION: Sini decoction can promote the expression of GST gene, which may be related to its protective effect on ischemic myocardium.
