Role of polymerase ? in DNA metabolism and genomic instability
- VernacularTitle:DNA聚合酶?可能参与了更广泛的细胞反应并引起遗传不稳定
- Author:
Guliang WANG
;
Yingnian YU
- Publication Type:Journal Article
- Keywords:
DNA polymerase ?;
base excision repair;
DNA replication;
DNA, recombinant;
Genomic instability
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The major role of DNA polymerase ? was thought to be limited in its involvement in short patch base excision repair by removing 5'-deoxyribose phosphate and base insertion. However, the recent researches indicate that polymerase ? might take part in a wide spectrum of DNA metabolism reactions, including long patch base excision repair, DNA replication, recombination, meiosis and transleisional DNA synthesis. Because of its wide and important cellular function, an inappropriate intracellular polymerase ? level might be associated with genomic instability. Down-regulation or mutation of polymerase ? is mutagenic due to deficient in DNA repair, while overexpression of this error-prone ? polymerase might perturb the normal function of other accurate polymerases and cause genomic instability as well.
