Epoxyeicosatrienoic acid: The signal transduction
- VernacularTitle:环氧-二十碳三烯酸:细胞内信号转导通路
- Author:
Wenying WANG
;
Xiangjun ZENG
;
Like ZHANG
- Publication Type:Journal Article
- Keywords:
Cytochrome P-450;
Signal Transduction;
Epoxy compounds.
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Cytochrome P450 monoxygenase converts arachionic acid to four epoxyeicosatrienoic acid regiosomes: 5,6-EET(epoxyeicosatrienoic acid);8,9-EET; 11,12-EET and 14,15-EET.Recent studies show that EETs are involved in signal transduction. EETs open Ca 2+ -sensitive K + channel and inhibit Na + channel,Ca 2+ -sensitive Cl - channel and so on. What is more ,EETs have been demonstrated to activate PP60 c-src and initiate a tyrosine kinase cascade that mediates mitogenic effects.
