Differentiation of Monocyte derived Dendritic Cells in Patients with Psoriasis
- VernacularTitle:银屑病患者外周血单核细胞向树突状细胞分化能力的研究
- Author:
Kejian ZHU
;
Weifang ZHOU
;
Limin LAO
;
Min ZHENG
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Dendritic cells;
Cell differentiation;
Monocytes
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differentiation of dendritic cells from monocytes of the peripheral blood in patients with psoriasis. Methods Flow cytometry was used to analyze the phenotype of monocyte derived dendritic cells (MoDC). The capacity of MoDC to stimulate the proliferation of T lymphocytes was evaluated by allogeneic mixed lymphocyte reaction. Results Monocytes in the peripheral blood of patients with psoriasis could differentiate into dendritic cells. Expression of CD40, CD80, CD86 and HLA-DR by MoDC was significantly increased in patients with psoriasis compared with that in normal controls (P
