Immunohistochemical Study of Skin homing T Lymphocytes in Psoriasis Vulgaris
- VernacularTitle:寻常型银屑病皮肤中皮肤归巢T细胞免疫组化研究
- Author:
Shanyu CHEN
;
Sen YANG
;
Yu GAO
;
Quangui XIANG
;
Xuejun ZHANG
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Lymphocyte function associated antigen;
Receptors,lymphocyte homing
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of skin homing T lymphocytes in the development of psoriasis vulgaris(PV). Methods Indirect immunofluorescent double staining technique was employed to study the expression of infiltrating skin homing T lymphocytes in normal, uninvolved perilesional and lesional psoriatic skin in different stages (progressing, stable or regressing) and in normal human skin. Results ①Expression of cutaneous lymphocyte associated antigen (CLA) was found in the majority of CD3+T lymphocytes in normal human skin and in lesions of PV, and CD45RO phenotype was expressed in almost all CLA+T lymphocytes. ②In psoriatic lesions, the number of CD4+CLA+and CD8+CLA+cells was higher in progressive stage than that in stable stage(P
