Expression of Keratinocyte Growth Factor and Nerve Growth Factor in Psoriasis and Its Clinical Significance
- VernacularTitle:角质形成细胞生长因子及神经细胞生长因子在银屑病患者皮损中的表达
- Author:
Wenfei YAN
;
Min ZHENG
;
Guojun SUN
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Epidermal growth factor urogastrone;
Nerve growth factors;
Keratinocyte growth factor
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between keratinocyte growth factor (KGF), nerve growth factor(NGF)and psoriasis;and to study the interaction between keratinocytes and interstitial cells in psoriasis. Methods The expression of KGF, KGF receptor (KGFR), NGF, NGF receptor (NGFR), epidermal growth factor receptor (EGFR) and proliferating cell neuclear antigen (PCNA) was studied with immunohistochemical technique (SP) in lesional skin, non lesional skin and normal controls. Results Significant overexpression of KGF and KGFR was present in psoriatic basal cell layers and suprabasal cell layers compared to that in non lesional and normal controls (P0.05). Expression of KGF and KGFR was absent in dermis. Expression of NGF and NGFR was observed mainly in granular cell layers and upper spinous layers, and was significantly different between normal controls and non lesional, between non lesional and lesional skin (P
