Up-regulation of Expression of Phosphatidylinositol 3-kinase in Psoriatic Lesions
- VernacularTitle:银屑病患者皮损中磷脂酰肌醇3激酶过表达
- Author:
Xiaoyan ZHANG
;
Shengqing MA
;
Huitu LIU
- Publication Type:Journal Article
- Keywords:
Psoriasis;
1 Phosphatidylinositol 3 kinase
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between phosphatidylinositol 3 kinase (PI3-kinase) and the pathogenesis of psoriasis. Methods By dot hybridization, in situ hybridization and immunohistochemistry, expression of PI3 kinase was observed in twelve psoriatic and five normal epidermis. Results In psoriatic epidermis, expression of PI3 kinase gene and protein was elevated obviously compared with that of normal skin. Conclusion PI3 kinase may be closely associated with hyperproliferation of psoriatic keratinocytes.
