Expression of IL-8 and CXCR2 on Keratinocytes from Psoriatic Lesions
- VernacularTitle:白介素8及其受体CXCR2在银屑病角质形成细胞中的表达
- Author:
Ling TANG
;
Yizhi YU
;
Jun GU
;
Sujiang TAO
;
Wenya WANG
;
Shuxun LIU
;
Maorong ZHENG
;
Xuetao CAO
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Keratinocytes;
Interleukin-8;
CXCR2
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of IL-8 and CXCR2 on keratinocytes from psoriatic lesions and their roles on clinical and pathologic manifestations. Methods The chemotaxis of psoriatic lesional keratinocytes was detected by micropore loculus test. The concentration of IL-8 was determined in the cultured supernatants of psoriatic keratinocytes by ELISA. The expression of CXCR2 on keratinocytes from affected skin was tested by flow cytometry. Results The chemotaxis for neutrophils by the cultured supernatants of psoriatic lesional keratinocytes was significantly stronger than that by controls. The concentration of IL-8 in the cultured supernatants of psoriatic lesional keratinocytes was also increased. The expression of CXCR2 on psoriatic keratinocytes was significantly increased. Conclusions The psoriatic epidermal hyperproliferation may be correlated with up regulation of IL-8 production and CXCR2 expression on psoriatic keratinocytes. At the same time, the psoriatic inflammation may be partly related to the increase of secretion of IL-8, which has chemotactic capacity, by keratinocytes. IL-8 and CXCR2 may be involved in the pathogenesis of psoriasis.
