In Vitro Study on Th1/Th2 Shift Modulated by CTLA4Ig in Psoriasis
- VernacularTitle:CTLA4Ig诱导银屑病Th1/Th2转换的体外研究
- Author:
Heng YAN
;
Qingyi YE
;
Fei HAO
;
Dongping HUANG
;
Yue MAI
;
Baiyu ZHONG
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Chimeric proteins;
Th1 cells;
Th2 cells;
Interleukin 2;
Interleukin 4;
Interferon type Ⅱ
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate Th1/Th2 pattern of response in psoriasis and to study the effects of CTLA4Ig on Th1/Th2 shift in psoriasis. Methods The levels of IL-2, IFN-?and IL-4 were assessed by ELISA in the supernatant of cultured peripheral blood mononuclear cells (PBMCs) from 33 patients with psoriasis vulgaris and 20 healthy blood donors. Cytokine synthesis was induced by activation with phytohemagglutinin (PHA) and staphylococcal enterotoxin B (SEB) with or without CTLA4Ig. Results Levels of IL-2, IFN-?and IL-4 were markedly increased by PBMCs from psoriatic patients incubated with SEB (P
