Evidence for Psoriasis susceptibility Locus in China:Locus on Chromosome 6p21.3
- VernacularTitle:6号染色体上可能存在银屑病易感基因
- Author:
Hong WANG
;
Weida LIU
;
Hui LI
;
Jingjun ZHAO
;
Wei CHEN
;
Li JIN
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Chromosomes,human,pair 6;
Linkage(Genetics)
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the genetic base of psoriasis for Chinese patients, the positional candidate loci (D6S273?D6S276?D6S422?D6S299?D6S291?D4S1535?D4S1652?D4S171)previously reported in the regions 6p21.3 and 4q were studied in some carefully examined psoriatic families in order to establish whether the eight reported microsatellites loci(STRs) underlay susceptibility to psoriasis in different populations. Methods Two hundred and five probands with psoriasis vulgaris were identified from outpatients attending the Institute of Dermatology, Chinese Academy of Medical Sciences. Genotypes were generated at 8 polymorphic loci on chromosome 6p21 and 4q in 14 pedigrees. The results were analyzed parametrically by linkage 5.0 software. Results There was evidence for linkage to D6S273 in 6p21.3 (the LOD score was 1.26) . No evidence for linkage was obtained at other loci including three loci on chromosome 4q. Conclusions This study confirms the presence of a psoriasis susceptibility locus on chromosome 6p previously studied. It is shown that there may be psoriasis susceptibility locus D6S273 on chromosome 6p21.3 in the Chinese population.
