Monomers of Aloin,Cinnamic Acid and Sophocarpidine Acting as Potent Inhibitors of Tyrosinase
- VernacularTitle:芦荟素、肉桂酸、苦参碱对酪氨酸酶的抑制作用
- Author:
Cheng TAN
;
Wenyuan ZHU
;
Yan LU
;
Dong LIU
- Publication Type:Journal Article
- Keywords:
Monophenol monooxygenase;
Cinnamic acid;
Aloin;
Sophocarpidine
- From:
Chinese Journal of Dermatology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of monomers of aloin, cinnamic acid and sophocarpidine on the acitivity of tyrosinase,so as to provide depigmenting agents in the treatment of hyperpigmentation disorders and cosmetics additives as well. Methods Tyrosinase activity was estimated by measuring the oxidation rate of DL dopa. The inhibitory pattern of each monomers was determined according to their Lineweaver Burk curve as compared to controls. Results Aloin,cinnamic acid and sophocarpidine down regulated the activity of tyrosinase. The inhibitory rates were significantly higher in cinnamic acid group(2 mmol/L, 0.5 mmol/L), aloin group (2 mmol/L)and sophocarpidine group than those in hydroquinone group (0.5 mmol/L)(P
