Protective effect of calcium channel blocking agents against human hepatic ischemia-reperfusion injury
- VernacularTitle:钙通道阻滞药对人肝脏缺血再灌注损伤的保护作用
- Author:
Tie LI
;
Shuguang WANG
- Publication Type:Journal Article
- Keywords:
Reperfusion, injury;
Calcium channel blockers;
Verapamil
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the protective effect of calcium channel blocker, verapamil against human hepatic ischemia-reperfusion injury.MethodsThe patients undergoing lobe/segment hepatectomy were injected with 5?mg/2ml verapamil through vena gastroepiploica dextra before blocking hepatic portal.ResultsThe levels of free calcium ions in the hepatic cell and serum enzyme from the test group increased significantly than those of the control group. The degree of hepatic pathological injury was lower and the hepatic function restored earlier in test group.ConclusionCalcium channel blockers administered by hepatic portal vein before blocking hepatic portal have an important protective effect against human hepatic ischemia-reperfusion injury.
