A study on the gene alterations in 9 STR loci and Amelogenin locus in cancerous tissues
- VernacularTitle:肿瘤组织9个STR基因座及Amelogenin基因座突变
- Author:
Kaihui LIU
;
Zhanhai WANG
;
Anquan JI
- Publication Type:Journal Article
- Keywords:
STR loci;
Amelogenin locus;
Tumor tissues;
Genetic alteration
- From:
Chinese Journal of Forensic Medicine
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study genetic alterations in 9 STR loci and the Amelogenin locus in various tumor tissues. Methods twenty cancer tissues taken from 20 different unrelated individuals and their blood specimens were examined with Chelex-100 extraction of DNA, Profiler Plus PCR amplification and 310 Genetic Analyzer. Results All of the 10 STR loci exist genetic alterations. The genetic alterations occurred in 6out of 20 cases. The rate of genetic alteration was 30%. Six genetic alterations were found in one tumor tissue. Conclusion The forensic community has to take be cautious not to use the tumor tissue for personnel identification.
