Studies on the Metabolism of DX by Intestinal Bacteria and the Absorbed Components in Serum
- VernacularTitle:黄山药总皂苷肠内菌代谢及代谢产物吸收的研究
- Author:
Haiying MA
- Publication Type:Journal Article
- Keywords:
DX;
intestinal bacterial metabolism;
electron spurt ion mass spectroscopy(ESI-MS);
thin-layer chromatography(TLC);
dioscin;
diosgenin
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the in vitro and in vivo metabolism of DX by intestinal bacteria in rats and volunteers and the active components in serum of rat after oral administration of DX 900mg/kg METHODS:To detect DX and its metabolites in stool,urine and serum with TLC and EST-MS RESULTS:In vitro,DX was decomposed easily by rat and human intestinal bacteria,and various metabolites were found With prolongation of metablism,metabolite with molecular weight of 415 3 was shown to be corresponding to diosgenin in rat serum and in urine of rats and volunteers CONCLUSION:The above-mentioned DX was decomposed easily by intestinal bacterias and diosgenin was absorbed into serum after oral administration of DX
