Study on CsA Therapeutic Window Concentration in Renal Transplant Recipients
- VernacularTitle:肾移植受者环孢素A治疗窗浓度研究
- Author:
Jianghua WAN
;
Fengshuo JIN
;
Qiansheng LI
;
Jun JIANG
;
Yanfeng LI
;
Qing JIANG
;
Xuguang XU
;
Yong ZHANG
;
Fangqiang ZHU
- Publication Type:Journal Article
- Keywords:
Cyclosporine A;
renal transplantation;
therapeutic drug monitoring;
specific fluorescence polarization immunoassay(FPIA)
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish an optimal therapeutic window concentration of CsA trough levels in renal transplant recipients on triple immunosuppressants regimen METHODS:A total 1 874 samples from 268 renal transplant recipients were measured by fluorescence polarization immunoassay(FPIA) According to the duration after operation and clinical diagnoses ,the whole blood CsA trough levels were compared among subgroups RESULTS:The optimal therapeutic window concentration of CsA was 300～400?g/L(within 1 month after operation),250～350?g/L(2nd～3rd month),150～250?g/L(4th～6th month),100～200?g/L(7th～12th month)and 100～150?g/L(more than 12 months) CONCLUSION:The above mentioned therapeutic window concentratin of CsA trough levels was ideal for renal transplant recipients with no marked acute toxic effects and rejection reaction
