Impacts of Anisodamine(654-2) Combined with Exogenous Pulmonary Surfactant on Tomor Necrosis Factor (TNF-?),Structure Changes of Lung Tissue During Pig's Lung Ischemic-reperfusion Injury
- VernacularTitle:山莨菪硷、外源性肺表面活性物质对猪肺缺血—再灌注TNF-?含量及肺组织结构的影响
- Author:
Youhua DENG
;
Zhengheng GUO
;
Hongming CHEN
- Publication Type:Journal Article
- Keywords:
654-2;
,Exogeneous pulmonary surfactant;
Pulmonary ischemic-reperfusion injury;
Tumor necrosis factor-?;
Pathological examination
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of anisodamine (654-2) combined with exogenous pulmonary surfactant (PS) on tumor necrosis (TNF- ?) ,structure of lung tissue changes during pig's lung ischemic-reperfusion injury. Methods 24 pigs ,approximately 45-day-old, were randomly divided into four groups: a control group,a 654-2 group,a PS group and a 654-2 plus PS group. The TNF-? concentration of every lung was analysed with ELISA methods at the point of pre-clamping right pulmonary aortery,post-clamping 60',90'(opening),post-unclamping 60',90',120'.Finally ,we examined the pathologic changes of the lungs. Results After clamping right pulmonary artery , TNF-? concentrations in every experimental groups were significantly lower than that of the control group (all P
