A Study on the Relationship Between Serum Levels of Hyaluronic Acid,Type Ⅳ Collagen, Laminin and Hepatic Fibrosis in Patients with Chronic Hepatitis B
- VernacularTitle:血清透明质酸、Ⅳ型胶原、层粘蛋白水平与慢性乙型肝炎肝纤维化的关系
- Author:
Xiaochun WANG
;
Lipeng LIU
;
Su LONG
- Publication Type:Journal Article
- Keywords:
Hyaluronate;
Type Ⅳ collagen;
Laminin;
Chronic hepatitis B;
Liver fibrosis
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between levels of hyaluronic acid(HA),type Ⅳ collagen(ⅣC),Laminin (LN) in sera and hepatic fibrosis in patients with chronic hepatitis B.Methods 252 sera from patients with chronic hepatitis B were collected to measure hyaluronate,type Ⅳ collagen,laminin by radioimmunoassay,and sera HBV-DNA were also tested by quantitative fluorescence PCR respectively.Results Serum concentrations of HA,ⅣC and LN were remarkably increased with the progression of the disease,and reached the highest levels in chronic severe hepatitis and liver cirrhosis(P
