Effect of TNF-? and IL-1? on the evolution of pancreatic encephalopathy
- VernacularTitle:TNF-?,IL-1?在胰性脑病发病机制中的作用
- Author:
Jun CHENG
;
Yakui ZHOU
;
Jiwei CHEN
;
Haian SHI
- Publication Type:Journal Article
- Keywords:
PANCREATITIS/pathol;
BRAIN/pathol;
PANCREAS/pathol;
TUMOR NECROSIS FACTOR-?;
INTERLEUKIN-1;
DISEASE MODELS,ANIMAL
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the damaging effect of tumor necrosis factor-alpha (TNF-?) and Interleukin-1?(IL-1?) on brain of rats in acute pancreatitis(AP). Mothods AP pancreatitis model in rats was induced by retrograde injection of 5% sodium taurocholate into the pancreatobiliary duct(1ml/kg body weight), then pretreated with normal saline (NS) or TNF-??IL-1?, TNF-? plus IL-1? respectively. Animals were killed at 5 h after drugs administration. The changes of brain water contents, leukocyte accumulation and adhesion were measured, and pathological studies of pancreas and brain were also performed. Results In groups with inflammatory cytokines pretreated, brain water contents, leukocyte accumulation and adhesion increased more significantly than those in control group and in NS pretreated group(P0.05). Conclusions Inflammatory cytokines such as TNF-? and IL-1? play important roles in the formation and acceleration of the brain damage in acute pancreatitis.
